Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779406 | 1.00 | KDM4E (0.42) | KDM4EL3MBTL1HSD11B1LTA4HPIK3CD | |
| SCHEMBL29779388 | 0.90 | KDM4E (0.47) | KDM4EL3MBTL1LTA4HPIK3CDTSHR | |
| SCHEMBL7384750 | 0.80 | KDM4E (0.52) | KDM4EL3MBTL1LTA4HPIK3CDTSHR | |
| SCHEMBL4513010 | 0.77 | KDM4E (0.47) | KDM4EL3MBTL1LTA4HPIK3CDTSHR | |
| SCHEMBL25043948 | 0.76 | HSD11B1 (0.37) | HSD11B1CYP11B2 | |
| SCHEMBL25043883 | 0.76 | HSD11B1 (0.37) | HSD11B1CYP11B2 | |
| Oxirane SCHEMBL10529044 | 0.76 | TP53 (0.44) | KDM4EL3MBTL1PIK3CDTSHRCYP1A2 | |
| SCHEMBL22442274 | 0.75 | CHRM2 (0.39) | KDM4EL3MBTL1PIK3CDTSHRCYP1A2 | |
| SCHEMBL26128555 | 0.75 | KDM4E (0.44) | KDM4EL3MBTL1LTA4HPIK3CDTSHR | |
| SCHEMBL14835319 | 0.74 | L3MBTL1 (0.48) | KDM4EL3MBTL1LTA4HPIK3CDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114716370-A | Pyridine-containing polycyclic derivative inhibitor, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-07-08 | — | — | CN | disclosed |