Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 11/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28840055 | 0.79 | GRIN2D (0.41) | PDE10ARETGRIN2DGRIN3BGRIN1 | |
| SCHEMBL21812435 | 0.78 | ADRA1A (0.47) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29483156 | 0.77 | HRH3 (0.52) | PDE10APDE3BPDE3ARET | |
| SCHEMBL26620577 | 0.76 | PDE10A (0.47) | PDE10APDE3BPDE3ARET | |
| SCHEMBL23708113 | 0.76 | PDE10A (0.47) | PDE10APDE3BPDE3ARET | |
| SCHEMBL29994597 | 0.76 | PIK3CD (0.50) | PDE10APDE3BPDE3ARETPIK3CD | |
| SCHEMBL28887108 | 0.76 | PIK3CD (0.50) | PDE10APDE3BPDE3ARETPIK3CD | |
| SCHEMBL7947301 | 0.75 | ACACB (0.41) | PDE10APDE3BPDE3A | |
| SCHEMBL7961553 | 0.75 | ACACB (0.41) | PDE10APDE3BPDE3A | |
| SCHEMBL7957015 | 0.75 | ACACB (0.41) | PDE10APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166642-A1 | NITROGEN-CONTAINING POLYCYCLIC FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF | 北京志健金瑞生物医药科技有限公司 | 2022-08-11 | — | — | WO | disclosed |