Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 11/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957015 | 1.00 | ACACB (0.41) | ACACBLIPGHRH3LSSHCRTR1 | |
| SCHEMBL7961553 | 1.00 | ACACB (0.41) | ACACBLIPGHRH3LSSHCRTR1 | |
| SCHEMBL7958355 | 0.92 | HRH3 (0.42) | ACACBHRH3LSSHCRTR1HCRTR2 | |
| SCHEMBL7954744 | 0.85 | FPR2 (0.43) | ACACBLIPGHRH3HCRTR1HCRTR2 | |
| SCHEMBL5632542 | 0.85 | ACACB (0.43) | ACACBLIPGHRH3OXTRAVPR1A | |
| SCHEMBL7956252 | 0.81 | LIPG (0.60) | LIPGHRH3 | |
| SCHEMBL7961497 | 0.81 | LIPG (0.60) | LIPGHRH3 | |
| SCHEMBL7956524 | 0.81 | LIPG (0.60) | LIPGHRH3 | |
| SCHEMBL7956682 | 0.81 | ACACB (0.43) | ACACBLIPGHRH3PDE3BPDE3A | |
| SCHEMBL7956861 | 0.81 | ACACB (0.51) | ACACBLSSPDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |