Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 4/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13203383 | 0.95 | OGA (0.34) | OGAALDH1A1SMN1; SMN2FAAHACKR3 | |
| Trifluoroacetic Acid SCHEMBL2978088 | 0.93 | NPC1 (0.33) | NPC1RAB9AF2F10PRSS1 | |
| Trifluoroacetic Acid SCHEMBL2977941 | 0.93 | NPC1 (0.36) | NPC1RAB9AF2F10PRSS1 | |
| Trifluoroacetic Acid SCHEMBL2661161 | 0.93 | GCK (0.31) | F2F10PRSS1OGAACKR3 | |
| Trifluoroacetic Acid SCHEMBL2968757 | 0.92 | NPC1 (0.33) | NPC1RAB9AF2F10PRSS1 | |
| Trifluoroacetic Acid SCHEMBL2972773 | 0.92 | ALDH1A1 (0.40) | ATMALDH1A1SMN1; SMN2MAPTTP53 | |
| Trifluoroacetic Acid SCHEMBL2963156 | 0.92 | NPC1 (0.35) | NPC1RAB9AF2F10PRSS1 | |
| Trifluoroacetic Acid SCHEMBL2977701 | 0.92 | LMNA (0.31) | F2F10PRSS1OGASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2660744 | 0.92 | OGA (0.31) | F2F10PRSS1OGA | |
| Trifluoroacetic Acid SCHEMBL2661305 | 0.92 | SLC2A1 (0.32) | F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410087-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-04-02 | — | — | US | disclosed |
| EP-2508524-A2 | Indole compound | Takeda Pharmaceutical Company Limited (JP) | 2012-10-10 | — | — | EP | disclosed |
| US-7777047-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-17 | — | — | US | disclosed |
| US-20100144702-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | US | disclosed |
| US-20100137610-A1 | Indole compound | YASUMA TSUNEO | 2010-06-03 | — | — | US | disclosed |
| US-7718798-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-18 | — | — | US | disclosed |
| US-7652133-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-26 | — | — | US | disclosed |
| US-20090286975-A1 | Indole compound | YASUMA TSUNEO | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144702-A1 | INDOLE COMPOUND | GCKR, GPR119, SLC5A1 | NPC1 2480/4885RAB9A 3121/4885F2 3253/4885 |
| US-20100137610-A1 | Indole compound | GCKR, GPR119, SLC5A1 | NPC1 2480/4885RAB9A 3121/4885F2 3253/4885 |
| US-20090286975-A1 | Indole compound | GCKR, GPR119, SLC5A1 | NPC1 2480/4885RAB9A 3121/4885F2 3253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.