Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.60 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTR5A | P47898 | 1/20 | 0.55 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31153237 | 0.91 | MCHR1 (0.61) | LMNACYP1A2CYP2D6THRBALOX15 | |
| SCHEMBL25634129 | 0.91 | MCHR1 (0.61) | LMNACYP1A2CYP2D6THRBALOX15 | |
| SCHEMBL1875671 | 0.90 | NISCH (0.63) | LMNACYP1A2CYP2D6THRBALOX15 | |
| SCHEMBL18870180 | 0.84 | MCHR1 (0.75) | MCHR1CYP3A4 | |
| SCHEMBL8316102 | 0.84 | MAPKAPK2 (0.55) | LMNAMAPKAPK2MCHR1MAOAMAOB | |
| SCHEMBL8316089 | 0.84 | MAPKAPK2 (0.55) | LMNAMAPKAPK2KMT2AMCHR1MAOA | |
| SCHEMBL25634009 | 0.81 | MCHR1 (0.70) | MAPKAPK2RAD52KMT2ANISCHMCHR1 | |
| SCHEMBL31153243 | 0.79 | HRH3 (0.58) | LMNACYP1A2CYP2D6ALOX15HSD17B10 | |
| SCHEMBL25634296 | 0.79 | HRH3 (0.58) | LMNACYP1A2CYP2D6ALOX15HSD17B10 | |
| SCHEMBL14924864 | 0.78 | HSD17B10 (0.67) | LMNACYP1A2CYP2D6THRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772245-B2 | Inhibitors of histone deacetylase | MIIKANA THERAPEUTICS, INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20060199829-A1 | Inhibitors of histone deacetylase | MIIKANA THERAPEUTICS, INC. | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199829-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC2, HDAC11 | LMNA 1126/4885CYP1A2 2392/4885CYP2D6 4120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.