SCHEMBL25634009

SCHEMBL25634009

c1ccc(COc2ccc3c4c([nH]c3c2)CCNCC4)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 7/20 0.70
CYP3A4 P08684 1/20 0.60
HTR2C P28335 2/20 0.54
HTR2A P28223 1/20 0.54
CTSV O60911 1/20 0.53
CTSL P07711 1/20 0.53
ADRA2A P08913 1/20 0.51
ADRA2B P18089 1/20 0.51
ADRA2C P18825 1/20 0.51
HTR7 P34969 1/20 0.51
NISCH Q9Y2I1 1/20 0.51
HTR2B P41595 1/20 0.50
MAOB P27338 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
MAOA P21397 1/20 0.48
IMPDH2 P12268 1/20 0.48
MAPKAPK2 P49137 1/20 0.47
RAD52 P43351 1/20 0.45
KMT2A Q03164 1/20 0.45
GABRA1 P14867 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1875671 0.91 NISCH (0.63) MCHR1CYP3A4CTSVCTSLADRA2A
SCHEMBL31153237 0.90 MCHR1 (0.61) MCHR1CYP3A4HTR2CHTR2ACTSV
SCHEMBL25634129 0.90 MCHR1 (0.61) MCHR1CYP3A4HTR2CHTR2ACTSV
SCHEMBL25634070 0.88 MCHR1 (0.57) MCHR1CYP3A4HTR2CHTR2ACTSV
SCHEMBL12927682 0.83 MCHR1 (1.00) MCHR1CYP3A4
Hydrochloric Acid SCHEMBL1005571 0.82 MCHR1 (0.98) MCHR1CYP3A4
SCHEMBL25634007 0.82 MCHR1 (0.61) MCHR1CYP3A4CTSVCTSLMAOA
SCHEMBL25634072 0.82 HTR2A (0.59) MCHR1CYP3A4HTR2CHTR2AADRA2A
SCHEMBL2978779 0.81 LMNA (0.63) MCHR1CYP3A4CTSVCTSLADRA2A
SCHEMBL25189080 0.77 HTR7 (0.81) MCHR1CYP3A4HTR2CHTR2AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250235463-A1 PHENOXY AND BENZYLOXY SUBSTITUTED PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. 2025-07-24 US disclosed
US-12295959-B2 Phenoxy and benzyloxy substituted psychoplastogens and uses thereof DELIX THERAPEUTICS, INC. (US) 2025-05-13 US disclosed
US-20240335454-A1 PHENOXY AND BENZYLOXY SUBSTITUTED PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. 2024-10-10 US disclosed
WO-2023114313-A1 PHENOXY AND BENZYLOXY SUBSTITUTED PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. (US) 2023-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240335454-A1 PHENOXY AND BENZYLOXY SUBSTITUTED PSYCHOPLASTOGENS AND USES THEREOF GAP43, BDNF, GRIN2A MCHR1 633/4885CYP3A4 4129/4885HTR2C 88/4885
US-12295959-B2 Phenoxy and benzyloxy substituted psychoplastogens and uses thereof GAP43, BDNF, GRIN2A MCHR1 633/4885CYP3A4 4129/4885HTR2C 88/4885
US-20250235463-A1 PHENOXY AND BENZYLOXY SUBSTITUTED PSYCHOPLASTOGENS AND USES THEREOF GAP43, BDNF, GRIN2A MCHR1 633/4885CYP3A4 4129/4885HTR2C 88/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.