Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 10/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.48 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21198788 | 0.89 | BCHE (0.58) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL21198787 | 0.89 | BCHE (0.58) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL28489345 | 0.88 | BCHE (0.57) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL28489343 | 0.88 | BCHE (0.57) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL21206426 | 0.83 | BCHE (0.54) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL28485695 | 0.83 | BCHE (0.54) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL4789433 | 0.82 | CHRNB2 (0.53) | BCHETMEM97SIGMAR1CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL25368401 | 0.78 | CARM1 (0.56) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL1787933 | 0.78 | CHRNB2 (0.50) | BCHECARM1PRMT6PRMT8TMEM97 | |
| SCHEMBL21198792 | 0.78 | PDCD1 (0.59) | BCHECARM1PRMT6PRMT8TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743425-B1 | 2,8-DIACYL-2,8-DIAZASPIRO[5.5]UNDECANE COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2024-11-27 | — | — | EP | disclosed |
| US-11414418-B2 | Compounds useful as immunomodulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11414418-B2 | Compounds useful as immunomodulators | CD74, HLA-DRB1, CD47 | BCHE 1249/4885CARM1 1383/4885PRMT6 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.