Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 9/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | CHKA | P35790 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29789777 | 0.86 | WDR5 (0.54) | WDR5DRD2DRD4DRD3PDE4B | |
| SCHEMBL29789664 | 0.85 | CHKA (0.56) | WDR5DRD2DRD4DRD3JAK2 | |
| SCHEMBL20896682 | 0.82 | WDR5 (0.62) | WDR5DRD2DRD4DRD3PDE4B | |
| SCHEMBL29789743 | 0.82 | WDR5 (0.62) | WDR5DRD2DRD4DRD3PDE4B | |
| SCHEMBL19496728 | 0.81 | AOC3 (0.52) | ADRA2AADRA2BADRA2CTMEM97SIGMAR1 | |
| SCHEMBL28822793 | 0.79 | WDR5 (0.51) | WDR5JAK2JAK1TYK2JAK3 | |
| SCHEMBL29789668 | 0.78 | WDR5 (0.60) | WDR5SMN1; SMN2 | |
| SCHEMBL20896835 | 0.78 | WDR5 (0.60) | WDR5SMN1; SMN2 | |
| SCHEMBL20896853 | 0.74 | WDR5 (0.54) | WDR5DRD2PDE4BNCF1 | |
| SCHEMBL29789647 | 0.74 | WDR5 (0.54) | WDR5DRD2PDE4BNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109195965-B | Inhibitors of WDR5 protein-protein binding | 普罗佩纶治疗公司 | 2022-07-26 | — | — | CN | disclosed |