Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | WDR5 | P61964 | 9/20 | 0.46 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28822819 | 0.84 | WDR5 (0.42) | ALDH1A1WDR5MAPTLMNACYP1A2 | |
| SCHEMBL20896611 | 0.82 | WDR5 (0.57) | WDR5 | |
| SCHEMBL20896556 | 0.82 | WDR5 (0.57) | WDR5 | |
| SCHEMBL29789992 | 0.82 | WDR5 (0.57) | WDR5 | |
| SCHEMBL29789889 | 0.82 | WDR5 (0.57) | WDR5 | |
| SCHEMBL25387406 | 0.81 | MAPT (0.46) | ALDH1A1WDR5GPR174MAPTLMNA | |
| SCHEMBL20606591 | 0.81 | MAPT (0.47) | ALDH1A1WDR5GPR174MAPTLMNA | |
| SCHEMBL20606363 | 0.81 | ALDH1A1 (0.48) | ALDH1A1WDR5GPR174MAPTLMNA | |
| SCHEMBL20896811 | 0.81 | ALDH1A1 (0.48) | ALDH1A1WDR5GPR174MAPTLMNA | |
| SCHEMBL20606364 | 0.81 | ALDH1A1 (0.48) | ALDH1A1WDR5GPR174MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109195965-B | Inhibitors of WDR5 protein-protein binding | 普罗佩纶治疗公司 | 2022-07-26 | — | — | CN | disclosed |