Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 3/20 | 0.39 |
| ▸ | FBP1 | P09467 | 13/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25607618 | 0.79 | FBP1 (0.36) | VCPFBP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL24618587 | 0.76 | CA12 (0.31) | CA12CA1CA9 | |
| SCHEMBL24618591 | 0.70 | CA12 (0.33) | CA12CA1CA9 | |
| SCHEMBL29792007 | 0.67 | TLR4 (0.35) | FBP1ALDH1A1LMNAMAPT | |
| SCHEMBL5680352 | 0.65 | FBP1 (0.42) | VCPFBP1ALDH1A1LMNAMAPT | |
| SCHEMBL5680349 | 0.65 | FBP1 (0.42) | VCPFBP1ALDH1A1LMNAMAPT | |
| SCHEMBL29792003 | 0.65 | GRM5 (0.38) | FBP1 | |
| SCHEMBL25607528 | 0.62 | FBP1 (0.56) | VCPFBP1ALDH1A1LMNAMAPT | |
| SCHEMBL30320150 | 0.62 | FBP1 (0.56) | VCPFBP1ALDH1A1LMNAMAPT | |
| SCHEMBL30320183 | 0.61 | VCP (0.44) | VCPFBP1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867553-A | Diaminopyrazolo [1,5-a ] pyrimidine-6-carbonitrile compounds as adenosine 2A receptor and adenosine 2B receptor antagonists | 巴格沃克斯研究有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4121431-A1 | DIAMINOPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBONITRILE COMPOUNDS AS ADENOSINE 2A RECEPTOR AND ADENOSINE 2B RECEPTOR ANTAGONIST | Bugworks Research, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| WO-2022149167-A1 | DIAMINOPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBONITRILE COMPOUNDS AS ADENOSINE 2A RECEPTOR AND ADENOSINE 2B RECEPTOR ANTAGONIST | BUGWORKS RESEARCH INDIA PVT LTD (IN) | 2022-07-14 | — | — | WO | disclosed |