Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28890742 | 1.00 | KEAP1 (0.49) | KEAP1ERN1PRMT6DYRK3DYRK1A | |
| SCHEMBL8732969 | 0.77 | KEAP1 (0.49) | KEAP1ERN1PRMT6KDM4EALDH1A1 | |
| SCHEMBL1346355 | 0.77 | ERN1 (0.54) | KEAP1ERN1PRMT6ALDH1A1L3MBTL1 | |
| SCHEMBL29570276 | 0.77 | ERN1 (0.54) | KEAP1ERN1PRMT6ALDH1A1L3MBTL1 | |
| SCHEMBL12303915 | 0.75 | PRMT6 (0.47) | KEAP1ERN1PRMT6KDM4EALDH1A1 | |
| SCHEMBL8308133 | 0.74 | KDM4E (0.52) | DYRK3DYRK1ADYRK2DYRK1BKDM4E | |
| SCHEMBL2164241 | 0.74 | KDM4E (0.52) | DYRK3DYRK1ADYRK2DYRK1BKDM4E | |
| SCHEMBL2164243 | 0.74 | KDM4E (0.52) | DYRK3DYRK1ADYRK2DYRK1BKDM4E | |
| SCHEMBL5666139 | 0.73 | KDM4E (0.58) | DYRK3DYRK1ADYRK2DYRK1BKDM4E | |
| SCHEMBL5666137 | 0.73 | KDM4E (0.58) | DYRK3DYRK1ADYRK2DYRK1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |