Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 13/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29519472 | 0.94 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29519497 | 0.94 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29519462 | 0.94 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29351019 | 0.87 | OPRD1 (0.61) | OPRD1OPRM1OPRK1 | |
| SCHEMBL31257004 | 0.87 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL4405062 | 0.87 | SLC7A5 (0.55) | OPRD1OPRM1OPRK1 | |
| SCHEMBL4405069 | 0.87 | SLC7A5 (0.55) | OPRD1OPRM1OPRK1 | |
| SCHEMBL15133708 | 0.86 | OPRD1 (0.53) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29658943 | 0.86 | MME (0.60) | OPRD1OPRM1OPRK1PTGS1GSTK1 | |
| SCHEMBL29658873 | 0.86 | MME (0.60) | OPRD1OPRM1OPRK1PTGS1GSTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4351619-A1 | METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1 | Mallinckrodt Pharmaceuticals Ireland Limited (IE) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022261102-A1 | METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1 | MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED (IE) | 2022-12-15 | — | — | WO | disclosed |
| EP-4051310-A1 | METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1 AND LOW MEAN ARTERIAL PRESSURE | Mallinckrodt Hospital Products IP Unlimited Company (IE) | 2022-09-07 | — | — | EP | disclosed |