Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 10/20 | 0.38 |
| ▸ | TACR3 | P29371 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17596684 | 1.00 | ALDH1A1 (0.40) | ALDH1A1MAPTAVPR1ATACR3KDM4E | |
| SCHEMBL17595643 | 0.80 | KDM4E (0.43) | ALDH1A1AVPR1ATACR3KDM4EP2RX7 | |
| SCHEMBL930214 | 0.72 | TACR3 (0.52) | TACR3SMN1; SMN2NPC1TP53TSHR | |
| SCHEMBL14635101 | 0.72 | TACR3 (0.52) | TACR3SMN1; SMN2NPC1TP53TSHR | |
| Hydrochloric Acid SCHEMBL14634796 | 0.71 | TACR3 (0.51) | TACR3SMN1; SMN2NPC1TP53TSHR | |
| Hydrochloric Acid SCHEMBL2565540 | 0.71 | TACR3 (0.51) | TACR3SMN1; SMN2NPC1TP53TSHR | |
| SCHEMBL930180 | 0.69 | TACR3 (0.54) | TACR3 | |
| SCHEMBL2419530 | 0.67 | ALDH1A1 (0.60) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL12324357 | 0.67 | PLD1 (0.41) | ALDH1A1MAPTKDM4ENPC1GFER | |
| SCHEMBL15415552 | 0.66 | CRBN (0.39) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12338243-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2025-06-24 | — | — | US | disclosed |
| US-20220235062-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220235062-A1 | P2X7 MODULATORS | P2RX7, P2RX4, P2RX1 | ALDH1A1 1107/4885MAPT 4307/4885AVPR1A 746/4885 |
| US-12338243-B2 | P2X7 modulators | P2RX7, P2RX4, P2RX1 | ALDH1A1 1107/4885MAPT 4307/4885AVPR1A 746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.