Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250796 | 0.76 | KDM4E (0.52) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1038510 | 0.72 | ALDH1A1 (0.57) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3772763 | 0.72 | KMT2A (1.00) | KMT2AMEN1RAB9ANPC1HDAC6 | |
| SCHEMBL2977828 | 0.71 | HSD11B1 (0.46) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8037981 | 0.70 | IDO1 (0.45) | HSD11B1RAB9ANPC1ESRRA | |
| SCHEMBL10045223 | 0.69 | CYP3A4 (0.63) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7603669 | 0.69 | CXCR4 (0.63) | RAB9ANPC1ESRRAHDAC6 | |
| SCHEMBL10764797 | 0.69 | CXCR4 (0.63) | RAB9ANPC1ESRRAHDAC6 | |
| SCHEMBL11568521 | 0.69 | POLB (0.51) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5187559 | 0.69 | KMT2A (0.62) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776903-B2 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| EP-1578416-B1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2006-08-02 | — | — | EP | disclosed |
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | THPO, ADCYAP1R1, DPYD | KMT2A 2739/4885ALDH1A1 327/4885CYP3A4 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.