Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30954953 | 0.83 | GPR119 (0.52) | GPR119ALDH1A1JAK2JAK1NR1D1 | |
| SCHEMBL34474238 | 0.82 | GPR119 (0.50) | HSD11B1GPR119ALDH1A1JAK2JAK1 | |
| SCHEMBL4263388 | 0.81 | GPR119 (0.54) | HSD11B1GPR119ALDH1A1JAK2JAK1 | |
| SCHEMBL1624526 | 0.81 | HSD11B1 (0.66) | HSD11B1GPR119JAK2JAK1NR1D1 | |
| SCHEMBL24424613 | 0.81 | GPR119 (0.49) | GPR119ALDH1A1JAK2JAK1NR1D1 | |
| SCHEMBL30954995 | 0.80 | GPR119 (0.48) | HSD11B1GPR119ALDH1A1JAK2JAK1 | |
| SCHEMBL4212846 | 0.80 | HTR2A (0.56) | GPR119ALDH1A1STSHTR2AEPHX2 | |
| SCHEMBL4215215 | 0.79 | GPR119 (0.52) | GPR119ALDH1A1HTR2AEPHX2UBE2M | |
| SCHEMBL25609126 | 0.79 | HTR2A (0.46) | HSD11B1ALDH1A1NR1D1HTR2AUBE2M | |
| SCHEMBL19123612 | 0.79 | ALDH1A1 (0.51) | GPR119ALDH1A1JAK2JAK1NR1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761412-A | Substituted macrocyclic compounds and related methods of treatment | 阿尔克姆斯有限公司 | 2022-07-15 | — | — | CN | disclosed |