Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27076452 | 1.00 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4ECTSBSMN1; SMN2 | |
| SCHEMBL23213590 | 0.89 | CTSB (0.57) | ALDH1A1LMNAKDM4ECTSBSMN1; SMN2 | |
| SCHEMBL29739612 | 0.89 | CTSB (0.57) | ALDH1A1LMNAKDM4ECTSBSMN1; SMN2 | |
| SCHEMBL29796053 | 0.81 | GSPT1 (0.41) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL23213421 | 0.81 | GSPT1 (0.41) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL29795985 | 0.80 | LMNA (0.51) | ALDH1A1LMNAKDM4ECTSBSMN1; SMN2 | |
| SCHEMBL23213367 | 0.80 | LMNA (0.51) | ALDH1A1LMNAKDM4ECTSBSMN1; SMN2 | |
| SCHEMBL23213560 | 0.78 | LMNA (0.49) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL29795957 | 0.78 | LMNA (0.49) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL23214090 | 0.77 | GSPT1 (0.53) | ALDH1A1KDM4ESMN1; SMN2GSPT1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041231-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2022-08-17 | — | — | EP | disclosed |