Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 11/20 | 0.57 |
| ▸ | CHUK | O15111 | 10/20 | 0.57 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442009 | 1.00 | PDPK1 (0.59) | PDPK1IKBKBCHUKBTKPLK4 | |
| Hydrochloric Acid SCHEMBL1440567 | 0.98 | PDPK1 (0.57) | PDPK1IKBKBCHUKBTKPLK4 | |
| SCHEMBL3425595 | 0.84 | KEAP1 (0.58) | PDPK1IKBKBCHUKBTKAURKA | |
| SCHEMBL30050554 | 0.84 | KEAP1 (0.58) | PDPK1IKBKBCHUKBTKAURKA | |
| SCHEMBL986438 | 0.78 | IKBKB (0.41) | PDPK1IKBKBCHUKCHEK1MAP2K1 | |
| SCHEMBL3424440 | 0.74 | NUDT1 (0.48) | KDR | |
| SCHEMBL1651352 | 0.74 | PDPK1 (1.00) | PDPK1IKBKBCHUKBTKPLK4 | |
| SCHEMBL29567411 | 0.74 | PDPK1 (1.00) | PDPK1IKBKBCHUKBTKPLK4 | |
| SCHEMBL4687592 | 0.73 | IKBKB (1.00) | PDPK1IKBKBCHUKBTKRIPK1 | |
| Hydrochloric Acid SCHEMBL3796059 | 0.73 | PDPK1 (0.96) | PDPK1IKBKBCHUKBTKPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162888-B2 | Carboxamides as ubiquitin-specific protease inhibitors | VALO HEALTH, INC. (US) | 2024-12-10 | — | — | US | disclosed |
| WO-2022228302-A1 | HETEROAROMATIC CARBOXAMIDE COMPOUNDS AND ITS USE | BIONOVA PHARMACEUTICALS (SHANGHAI) LIMITED (CN) | 2022-11-03 | — | — | WO | disclosed |
| CN-114957242-A | Preparation and application of pyrido-heterocyclic compound as kinase inhibitor | 药雅科技(上海)有限公司 | 2022-08-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162888-B2 | Carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | PDPK1 1928/4885IKBKB 232/4885CHUK 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.