Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093381 | 1.00 | PTGS2 (0.43) | PTGS2PTGS1KCNH2GCKLRRK2 | |
| SCHEMBL23093139 | 0.85 | LRRK2 (0.48) | PTGS2PTGS1KCNH2LRRK2 | |
| SCHEMBL29802518 | 0.83 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL23093191 | 0.83 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL23093235 | 0.80 | PTGS2 (0.46) | PTGS2PTGS1KCNH2LRRK2 | |
| SCHEMBL29802440 | 0.80 | PTGS2 (0.46) | PTGS2PTGS1KCNH2LRRK2 | |
| SCHEMBL23111067 | 0.78 | PLAU (0.32) | — | |
| SCHEMBL29802464 | 0.77 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL23093419 | 0.77 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL23093460 | 0.69 | LRRK2 (0.48) | PTGS2PTGS1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4027993-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | The Broad Institute Inc. (US) | 2022-07-20 | — | — | EP | disclosed |