Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29179122 | 0.80 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1PDK4GPR119PIK3R1 | |
| SCHEMBL6352947 | 0.79 | MAPK1 (0.49) | MAPK1ESR2NR1H2PDK4GPR119 | |
| SCHEMBL24710927 | 0.77 | PDK4 (0.45) | MAPK1ESR2NR1H2PDK4DGAT2 | |
| SCHEMBL22944628 | 0.77 | NAMPT (0.48) | MAPK1ESR2NR1H2PDK4GPR119 | |
| SCHEMBL31357964 | 0.75 | HTR6 (0.49) | MAPK1PDK4DGAT2 | |
| SCHEMBL29197658 | 0.75 | ESR2 (0.55) | MAPK1ESR2NR1H2PDK4DGAT2 | |
| SCHEMBL7473234 | 0.75 | GPR119 (0.48) | MAPK1ESR2NR1H2PDK4DGAT2 | |
| SCHEMBL3642252 | 0.75 | PDK4 (0.47) | MAPK1ESR2NR1H2PDK4DGAT2 | |
| SCHEMBL29806135 | 0.75 | MAPK1 (0.45) | MAPK1ESR2NR1H2PDK4DGAT2 | |
| SCHEMBL27201656 | 0.75 | PDK4 (0.47) | MAPK1ESR2NR1H2PDK4DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022152852-A1 | ANTAGONISTS OF MRGX2 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-07-21 | — | — | WO | disclosed |