SCHEMBL29809206

SCHEMBL29809206

O=c1[nH]cc(-c2ccc(Cl)cc2)c(=O)[nH]1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.67
LMNA P02545 2/20 0.47
MAP4K4 O95819 1/20 0.41
GAA P10253 4/20 0.41
DPYD Q12882 1/20 0.41
ATAD2 Q6PL18 1/20 0.41
MAPT P10636 1/20 0.41
CYP19A1 P11511 1/20 0.41
TSHR P16473 1/20 0.41
THPO P40225 1/20 0.41
MTOR P42345 1/20 0.41
HTT P42858 1/20 0.41
HBB P68871 1/20 0.41
PMP22 Q01453 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MCL1 Q07820 1/20 0.40
TYMS P04818 1/20 0.40
KDM4E B2RXH2 3/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28409089 0.81 MEN1 (0.48) ALDH1A1MAP4K4GAAMAPTMCL1
SCHEMBL16653102 0.81 ALDH1A1 (0.67) ALDH1A1LMNAGAADPYDATAD2
SCHEMBL16652924 0.81 ALDH1A1 (0.67) ALDH1A1LMNAGAADPYDATAD2
SCHEMBL3485414 0.80 ALDH1A1 (1.00) ALDH1A1LMNAGAADPYDATAD2
SCHEMBL13314218 0.78 ALDH1A1 (0.53) ALDH1A1LMNAMAP4K4GAAKDM4E
SCHEMBL23772148 0.77 ALDH1A1 (0.61) ALDH1A1LMNAGAADPYDATAD2
SCHEMBL16652113 0.77 ALDH1A1 (0.61) ALDH1A1LMNAMAPTCYP19A1TSHR
SCHEMBL16652457 0.77 ALDH1A1 (0.68) ALDH1A1LMNAGAASMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL3562807 0.76 ALDH1A1 (0.51) ALDH1A1LMNAMAP4K4GAAKDM4E
SCHEMBL5801644 0.76 ALDH1A1 (0.64) ALDH1A1LMNAGAADPYDATAD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114835687-B AhR inhibitors 北京华森英诺生物科技有限公司 2023-09-05 CN disclosed
CN-114835687-A AhR inhibitors 重庆华森制药股份有限公司 2022-08-02 CN disclosed