Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 6/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | GNRHR | P30968 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | DPYD | Q12882 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28408957 | 0.83 | ALDH1A1 (0.41) | ALDH1A1LMNANOTUMTNKSTNKS2 | |
| SCHEMBL16652113 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNANOTUMTNKSTNKS2 | |
| SCHEMBL16653102 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNAATAD2BRD4DPYD | |
| SCHEMBL29809206 | 0.77 | ALDH1A1 (0.67) | ALDH1A1LMNAATAD2DPYDGAA | |
| SCHEMBL16652924 | 0.77 | ALDH1A1 (0.67) | ALDH1A1LMNAATAD2DPYDGAA | |
| SCHEMBL16652457 | 0.76 | ALDH1A1 (0.68) | ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL3485414 | 0.76 | ALDH1A1 (1.00) | ALDH1A1LMNAATAD2PARP1DPYD | |
| SCHEMBL28408958 | 0.72 | HTR1A (0.38) | ALDH1A1LMNAATAD2GNRHRDPYD | |
| SCHEMBL5801644 | 0.72 | ALDH1A1 (0.64) | ALDH1A1LMNAATAD2DPYDGAA | |
| SCHEMBL16455963 | 0.71 | BRD4 (0.43) | ALDH1A1LMNANOTUMTNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11679093-B2 | 2-naphthimidamides, analogues thereof, and methods of treatment using same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-06-20 | — | — | US | disclosed |
| US-20210251942-A1 | 2-NAPHTHIMIDAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME | UNIV COLORADO REGENTS (US) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11679093-B2 | 2-naphthimidamides, analogues thereof, and methods of treatment using same | TMPRSS2, TMPRSS4, TMPRSS15 | ALDH1A1 2417/4885LMNA 428/4885NOTUM 1317/4885 |
| US-20210251942-A1 | 2-NAPHTHIMIDAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME | TMPRSS2, TMPRSS4, TMPRSS15 | ALDH1A1 2417/4885LMNA 428/4885NOTUM 1317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.