Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 3/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 6/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.40 |
| ▸ | WNT3A | P56704 | 4/20 | 0.40 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23772148 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNANOTUMMAPTCYP19A1 | |
| SCHEMBL16652924 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| SCHEMBL16653102 | 0.77 | ALDH1A1 (0.67) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| SCHEMBL29809206 | 0.77 | ALDH1A1 (0.67) | ALDH1A1LMNADAOMAPTCYP19A1 | |
| SCHEMBL5801644 | 0.72 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| SCHEMBL6551744 | 0.71 | KIF11 (0.45) | DAOCOMTNOTUMMAPTTNKS | |
| SCHEMBL14466718 | 0.70 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| SCHEMBL8354646 | 0.70 | MAPK14 (0.53) | ALDH1A1COMTNOTUMTNKSTNKS2 | |
| SCHEMBL23796387 | 0.69 | IMPDH2 (0.44) | DAOTNKSPARP1 | |
| SCHEMBL30290070 | 0.69 | IMPDH2 (0.44) | DAOTNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875006-B1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2018-12-26 | — | — | EP | disclosed |
| US-9428465-B2 | Acid ceramidase inhibitors and their use as medicaments | FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA (IT) | 2016-08-30 | — | — | US | disclosed |
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | ASAH1, ASAH2, ACER2 | ALDH1A1 641/4885LMNA 2167/4885DAO 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.