SCHEMBL298165

SCHEMBL298165

Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1

nearest known ligand 0.66

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.66
KMT2A Q03164 2/20 0.63
MAPT P10636 2/20 0.60
MEN1 O00255 1/20 0.58
ALDH1A1 P00352 1/20 0.58
L3MBTL1 Q9Y468 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9894428 0.93 POLB (0.60) POLBKMT2AMAPTMEN1ALDH1A1
SCHEMBL299163 0.90 KMT2A (0.60) POLBKMT2AMAPTMEN1ALDH1A1
SCHEMBL31633659 0.90 MAPT (0.59) POLBKMT2AMAPTMEN1ALDH1A1
SCHEMBL14563025 0.89 POLB (0.57) POLBKMT2AMAPTMEN1ALDH1A1
SCHEMBL298783 0.86 MAPT (0.57) POLBKMT2AMAPTMEN1ALDH1A1
SCHEMBL14563011 0.85 ALDH1A1 (0.48) POLBKMT2AMAPTALDH1A1
SCHEMBL297862 0.81 ALDH1A1 (0.57) MAPTALDH1A1
SCHEMBL1274616 0.81 RAB9A (0.52) POLBMAPTALDH1A1
SCHEMBL17399561 0.80 ALDH1A1 (0.46) POLBKMT2AMAPTALDH1A1
SCHEMBL3211887 0.79 IRAK4 (0.49) POLBKMT2AMAPTMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013092942-A1 USE OF AMINOBENZAMIDE DERIVATIVES FOR CONTROLLING ANIMAL PARASITES SYNGENTA PARTICIPATIONS AG (CH) 2013-06-27 WO disclosed
US-8455399-B2 N-(4-perfluoroalkyl-phenyl)-4-triazolyl-benzamides as insecticides SYNGENTA CROP PROTECTION LLC (US) 2013-06-04 US disclosed
US-20130023571-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA CROP PROTECTION LLC (US) 2013-01-24 US disclosed
EP-2427439-B1 N-(4-PERFLUOROALKYL-PHENYL)-4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2013-01-16 EP disclosed
EP-2427439-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES Syngenta Participations AG (CH) 2012-03-14 EP disclosed
WO-2010127927-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130023571-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES PFAS, AADAC, FABP5 POLB 4481/4885KMT2A 1668/4885MAPT 3468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.