Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.64 |
| ▸ | HRH1 | P35367 | 8/20 | 0.64 |
| ▸ | HRH2 | P25021 | 5/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2981461 | 0.86 | LTA4H (0.56) | HRH3HRH1HRH2 | |
| SCHEMBL2975828 | 0.85 | SLC6A2 (0.58) | HRH3HRH1DRD2HTR2A | |
| SCHEMBL2975452 | 0.85 | HRH3 (0.55) | HRH3HRH1HRH2 | |
| SCHEMBL2981971 | 0.82 | HRH3 (0.65) | HRH3HRH1HRH2 | |
| SCHEMBL2984514 | 0.80 | HRH3 (0.65) | HRH3HRH1HRH2HTR2A | |
| SCHEMBL2984892 | 0.79 | HRH3 (0.64) | HRH3HRH1HRH2 | |
| SCHEMBL2990304 | 0.78 | HRH3 (0.55) | HRH3HRH1HRH2 | |
| SCHEMBL2989449 | 0.78 | HRH3 (0.47) | HRH3HRH1HRH2 | |
| SCHEMBL8567186 | 0.73 | HRH3 (0.52) | HRH3HRH1HRH2DRD2HTR2A | |
| SCHEMBL2975830 | 0.73 | SLC6A2 (0.55) | HRH3HRH1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K7 | HRH3 631/4885HRH1 698/4885HRH2 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.