Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CCND1 | P24385 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662487 | 0.75 | PAK1 (0.60) | PAK1ULK1KDM4EGAAMAPK8 | |
| SCHEMBL15264144 | 0.74 | PAK1 (0.62) | PAK1ULK1KDM4EGAAMAPK8 | |
| SCHEMBL9704728 | 0.73 | PDE4A (0.43) | PAK1ULK1KDM4EGAACDK4 | |
| SCHEMBL1551868 | 0.72 | PAK1 (0.56) | PAK1ULK1KDM4EGAAMAPK8 | |
| SCHEMBL14391351 | 0.71 | MAPK8 (0.60) | PAK1MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL11000513 | 0.70 | PAK1 (0.47) | PAK1ULK1KDM4EGAAMAPK8 | |
| SCHEMBL22278819 | 0.69 | ULK1 (0.41) | PAK1ULK1MAPK8TYRO3EGFR | |
| SCHEMBL1644969 | 0.69 | ALDH1A1 (0.38) | KDM4E | |
| SCHEMBL10999501 | 0.69 | PAK1 (0.49) | PAK1ULK1KDM4EGAAMAPK8 | |
| SCHEMBL10998140 | 0.69 | PAK1 (0.49) | PAK1ULK1KDM4EGAAMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464287-B1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2022-06-08 | — | — | EP | claimed |