Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 7/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.41 |
| ▸ | MERTK | Q12866 | 7/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9704732 | 0.82 | PAK1 (0.53) | PDE4APDE4BPDE4CPDE4DPAK1 | |
| SCHEMBL9704929 | 0.77 | PARP1 (0.40) | FLT3TYRO3MERTKGAS6AXL | |
| SCHEMBL29824345 | 0.73 | PAK1 (0.47) | PAK1CDK4CCND1CCND2CCND3 | |
| SCHEMBL9669702 | 0.72 | PARP1 (0.42) | TYRO3 | |
| SCHEMBL9705991 | 0.72 | PARP1 (0.47) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL9706003 | 0.70 | PARP1 (0.40) | — | |
| SCHEMBL9705258 | 0.70 | PARP1 (0.40) | CDK1CCNB1CDK2 | |
| SCHEMBL15264144 | 0.69 | PAK1 (0.62) | PAK1CDK4CCND1FLT3TYRO3 | |
| SCHEMBL7662487 | 0.67 | PAK1 (0.60) | PAK1CDK4CCND1FLT3TYRO3 | |
| SCHEMBL7851162 | 0.67 | PARP1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |