Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PLD2 | O14939 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3030225 | 0.95 | LEF1 (0.60) | LEF1TP53POLBNHERF1KDM4E | |
| SCHEMBL19885734 | 0.94 | LEF1 (0.61) | LEF1TP53POLBNHERF1NPC1 | |
| SCHEMBL6619949 | 0.89 | LEF1 (0.81) | LEF1TP53POLBNHERF1NPC1 | |
| SCHEMBL20275135 | 0.86 | LEF1 (0.62) | LEF1TP53POLBNHERF1NPC1 | |
| SCHEMBL3035898 | 0.85 | LEF1 (0.49) | LEF1KDM4EPIN1MAPT | |
| SCHEMBL6617416 | 0.84 | LEF1 (0.74) | LEF1TP53NPC1RAB9AKDM4E | |
| SCHEMBL13311254 | 0.84 | LEF1 (0.59) | LEF1TP53POLBNHERF1NPC1 | |
| SCHEMBL6816854 | 0.83 | NPC1 (0.67) | LEF1TP53POLBNPC1RAB9A | |
| SCHEMBL17414822 | 0.83 | LEF1 (0.48) | LEF1TP53POLBKDM4EALDH1A1 | |
| SCHEMBL20742974 | 0.81 | FLT3 (0.59) | LEF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587426-B1 | NEW ALKYLATING AGENTS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2022-08-10 | — | — | EP | disclosed |