Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 3/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593193 | 1.00 | NR1H2 (0.34) | NR1H2MAP3K5GPR119PORCNWNT3A | |
| SCHEMBL23751150 | 0.92 | ALDH1A1 (0.34) | PORCNALDH1A1HPGDHSD17B10MET | |
| SCHEMBL29836554 | 0.90 | NR1H2 (0.38) | NR1H2WNT3AMMP13ADAM17IGF1R | |
| SCHEMBL21593192 | 0.90 | NR1H2 (0.38) | NR1H2WNT3AMMP13ADAM17IGF1R | |
| SCHEMBL21593191 | 0.90 | NR1H2 (0.38) | NR1H2GPR119PORCNWNT3AMMP13 | |
| SCHEMBL23762288 | 0.88 | NR1H2 (0.34) | NR1H2MAP3K5PORCNWNT3AMMP13 | |
| SCHEMBL23762175 | 0.88 | UCHL1 (0.35) | NR1H2WNT3AMMP13ADAM17IGF1R | |
| SCHEMBL21593189 | 0.88 | NR1H2 (0.37) | NR1H2GPR119WNT3AHTR6ALDH1A1 | |
| SCHEMBL21593108 | 0.88 | NR1H2 (0.42) | NR1H2GPR119HTR6ALDH1A1HPGD | |
| SCHEMBL23762177 | 0.87 | WNT3A (0.35) | NR1H2PORCNWNT3AHTR6ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807273-B1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2022-08-03 | — | — | EP | disclosed |