Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 14/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 10/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27003504 | 1.00 | F11 (0.40) | F11KLK1KLKB1CYP3A4NOTUM | |
| SCHEMBL31174071 | 0.91 | F11 (0.40) | F11KLK1KLKB1CYP3A4NOTUM | |
| SCHEMBL30590414 | 0.84 | F11 (0.39) | F11KLK1KLKB1CYP3A4NOTUM | |
| SCHEMBL21357595 | 0.83 | F11 (0.49) | F11KLKB1CYP3A4F2F10 | |
| SCHEMBL29697761 | 0.83 | F11 (0.49) | F11KLKB1CYP3A4F2F10 | |
| SCHEMBL30995051 | 0.82 | F11 (0.41) | F11KLK1KLKB1CYP3A4NOTUM | |
| SCHEMBL16971771 | 0.82 | F11 (0.38) | F11KLK1KLKB1CYP3A4NOTUM | |
| SCHEMBL29227936 | 0.82 | F11 (0.41) | F11KLK1KLKB1CYP3A4NOTUM | |
| SCHEMBL29839754 | 0.81 | F11 (0.40) | F11KLK1KLKB1CYP3A4NOTUM | |
| SCHEMBL29839752 | 0.81 | F11 (0.40) | F11KLK1KLKB1CYP3A4NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304714-A1 | CRYSTALLINE FORMS OF (4S)-2 4-CHLORO-4-ETHYL-7 3-FLUORO-3 5-METHOXY-3 2,5-DIOXO-1 4-(TRIFLUOROMETHYL)-3 2H-6-AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)-5 DIBENZENAHEPTAPHANE-7 4-CARBOXAMIDE | Bayer Aktiengesellschaft (DE) | 2024-01-17 | — | — | EP | disclosed |
| EP-4304561-A1 | PHARMACEUTICAL DOSAGE FORMS COMPRISING (4S)-24-CHLORO-4-ETHYL-73-FLUORO-35-METHOXY-32,5- DIOXO-14-(TRIFLUOROMETHYL)-32H-6-AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)- DIBENZENAHEPTAPHANE-74-CARBOXAMIDE | Bayer Aktiengesellschaft (DE) | 2024-01-17 | — | — | EP | disclosed |
| CN-117337170-A | Comprises (4S) -2 4 -chloro-4-ethyl-7 3 -fluoro-3 5 -methoxy-3 2 5-dioxo-1 4 - (trifluoromethyl) -3 2 H-6-aza-3 (4, 1) -pyridine-1 (1) - [1,2,3]Triazole-2 (1, 2), 7 (1) -diphenyl heptatomato-7 4 Pharmaceutical dosage form of formamide | 拜耳公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-117015535-A | (4S)-2 4 -chloro-4-ethyl-7 3 -fluoro-3 5 -methoxy-3 2 5-dioxo-1 4 - (trifluoromethyl) -3 2 H-6-aza-3 (4, 1) -pyridine-1 (1) - [1,2,3]Triazole-2 (1, 2), 7 (1) -5-diphenylheptane-7 4 Crystalline forms of formamide | 拜耳公司 | 2023-11-07 | — | — | CN | disclosed |
| WO-2022189278-A1 | PHARMACEUTICAL DOSAGE FORMS COMPRISING (4S)-24-CHLORO-4-ETHYL-73-FLUORO-35-METHOXY-32,5- DIOXO-14-(TRIFLUOROMETHYL)-32H-6-AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)- DIBENZENAHEPTAPHANE-74-CARBOXAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2022-09-15 | — | — | WO | disclosed |
| WO-2022189279-A1 | CRYSTALLINE FORMS OF (4S)-24-CHLORO-4-ETHYL-73-FLUORO-35-METHOXY-32,5-DIOXO-14-(TRIFLUOROMETHYL)-32H-6-AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)-5 DIBENZENAHEPTAPHANE-74-CARBOXAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2022-09-15 | — | — | WO | disclosed |
| WO-2022189280-A1 | SOLVATES OF (4S)-24-CHLORO-4-ETHYL-73-FLUORO-35-METHOXY-32,5-DIOXO-14-(TRIFLUORO-METHYL)-32 H-6- AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)-DIBENZENAHEPTAPHANE-74-CARBOXAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2022-09-15 | — | — | WO | disclosed |