Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779514 | 0.84 | L3MBTL1 (0.60) | L3MBTL1PTGDR2HTR6COMTKDM4E | |
| SCHEMBL13239579 | 0.83 | L3MBTL1 (0.46) | L3MBTL1SMN1; SMN2LMNAPTGDR2ALOX5 | |
| SCHEMBL2979262 | 0.83 | L3MBTL1 (0.46) | L3MBTL1SMN1; SMN2LMNAPTGDR2ALOX5 | |
| SCHEMBL13302164 | 0.83 | L3MBTL1 (0.59) | L3MBTL1PTGDR2HTR6COMTELANE | |
| SCHEMBL2447588 | 0.82 | L3MBTL1 (0.55) | L3MBTL1SMN1; SMN2LMNAPTGDR2ALOX5 | |
| SCHEMBL20488865 | 0.82 | L3MBTL1 (0.55) | L3MBTL1SMN1; SMN2LMNAPTGDR2HTR6 | |
| SCHEMBL2024287 | 0.82 | HTR6 (0.56) | L3MBTL1SMN1; SMN2PTGDR2HTR6COMT | |
| SCHEMBL1668563 | 0.82 | L3MBTL1 (0.58) | L3MBTL1PTGDR2HTR6COMTELANE | |
| SCHEMBL28523210 | 0.82 | L3MBTL1 (0.58) | L3MBTL1PTGDR2HTR6COMTKDM4E | |
| SCHEMBL12657360 | 0.82 | L3MBTL1 (0.58) | L3MBTL1SMN1; SMN2PTGDR2HTR6COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| WO-2007107221-A1 | 4-(PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | L3MBTL1 862/4885SMN1; SMN2 751/4885LMNA 2863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.