Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239579 | 1.00 | L3MBTL1 (0.46) | L3MBTL1PTGDR2CA2CA9ALOX5 | |
| SCHEMBL2984205 | 0.83 | L3MBTL1 (0.55) | L3MBTL1PTGDR2CA2CA9ALOX5 | |
| SCHEMBL1666450 | 0.83 | ENPP3 (0.40) | L3MBTL1PTGDR2CA2CA9ALOX5 | |
| SCHEMBL30301159 | 0.83 | ENPP3 (0.40) | L3MBTL1PTGDR2CA2CA9ALOX5 | |
| SCHEMBL8944119 | 0.83 | ENPP3 (0.40) | L3MBTL1PTGDR2CA2CA9ALOX5 | |
| SCHEMBL28905353 | 0.81 | ALOX5 (0.41) | L3MBTL1CA2CA9ALOX5HDAC1 | |
| SCHEMBL28502871 | 0.78 | ALOX5 (0.44) | L3MBTL1CA2CA9ALOX5HDAC1 | |
| SCHEMBL2979261 | 0.77 | CA2 (0.52) | L3MBTL1PTGDR2CA2CA9HDAC1 | |
| SCHEMBL1779514 | 0.76 | L3MBTL1 (0.60) | L3MBTL1PTGDR2KDM4EUBE2NHTR6 | |
| SCHEMBL28502706 | 0.75 | ALOX5 (0.41) | PTGDR2CA2CA9ALOX5HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | L3MBTL1 862/4885PTGDR2 343/4885CA2 2517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.