Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 14/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 13/20 | 0.54 |
| ▸ | CDK2 | P24941 | 12/20 | 0.54 |
| ▸ | CDK9 | P50750 | 11/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 7/20 | 0.44 |
| ▸ | CDK1 | P06493 | 6/20 | 0.44 |
| ▸ | PRKACA | P17612 | 6/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.44 |
| ▸ | CDC7 | O00311 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2989444 | 0.80 | CCNT1 (0.67) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL2988085 | 0.80 | CDK5 (0.67) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL27835141 | 0.79 | CDK5 (0.61) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL2984437 | 0.79 | CDK5 (0.61) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL12355043 | 0.79 | CDK5 (0.67) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL1838586 | 0.78 | CDK5 (0.60) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL2984404 | 0.78 | CDK5 (0.64) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL13521496 | 0.78 | CDK5 (0.65) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL2238419 | 0.78 | CDK5 (0.69) | CDK5CDK5R1CDK2CDK9CCNT1 | |
| SCHEMBL13521485 | 0.77 | CDK5 (0.58) | CDK5CDK5R1CDK2CDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125803-B1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | CENTRE NAT RECH SCIENT (FR) | 2013-04-10 | — | — | EP | disclosed |
| US-20100184790-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184790-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | BAD, PPOX, CASP3 | CDK5 15/4885CDK5R1 64/4885CDK2 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.