Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TAF1 | P21675 | 3/20 | 0.36 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27186134 | 0.89 | BRD9 (0.41) | BTKBRD9JAK2JAK1JAK3 | |
| SCHEMBL27186174 | 0.85 | BRD9 (0.40) | BRD9JAK2JAK1JAK3TAF1 | |
| SCHEMBL30853365 | 0.80 | BTK (0.39) | BTKCECR2BRD4 | |
| SCHEMBL29844104 | 0.74 | SOS1 (0.46) | — | |
| SCHEMBL27186376 | 0.74 | SOS1 (0.46) | — | |
| SCHEMBL27186378 | 0.74 | SOS1 (0.46) | — | |
| SCHEMBL30853318 | 0.68 | BTK (0.39) | BTKBRD9TAF1CECR2BRD4 | |
| SCHEMBL31316523 | 0.67 | MET (0.47) | MEN1KMT2APARP1JAK2JAK1 | |
| SCHEMBL21351692 | 0.67 | DYRK1A (0.51) | MEN1KMT2AJAK1JAK3 | |
| SCHEMBL30562059 | 0.65 | CHEK2 (0.38) | MEN1KMT2APARP1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |
| WO-2022187266-A1 | NOVEL SUBSTITUTED BICYCLI AZA-HETEROCYCLES AS SOS1 INHIBITORS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2022-09-09 | — | — | WO | disclosed |