Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.64 |
| ▸ | HRH1 | P35367 | 5/20 | 0.64 |
| ▸ | HRH2 | P25021 | 4/20 | 0.64 |
| ▸ | FLT4 | P35916 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | BMP4 | P12644 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.52 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.52 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984893 | 0.89 | HRH3 (0.62) | HRH3HRH1HRH2KCNH2 | |
| SCHEMBL2989450 | 0.85 | PRKCQ (0.49) | HRH3HRH1HRH2FLT4KDR | |
| SCHEMBL2981464 | 0.84 | LTA4H (0.55) | HRH3HRH1HRH2FLT4KDR | |
| SCHEMBL2975455 | 0.83 | FLT1 (0.57) | HRH3HRH1HRH2FLT4KDR | |
| SCHEMBL2981971 | 0.82 | HRH3 (0.65) | HRH3HRH1HRH2FLT4KDR | |
| SCHEMBL2984514 | 0.79 | HRH3 (0.65) | HRH3HRH1HRH2KDRMAPK1 | |
| SCHEMBL17120730 | 0.79 | LMNA (0.50) | SRCALDH1A1CYP1A2CHEK1LMNA | |
| SCHEMBL14714916 | 0.79 | HRH3 (1.00) | HRH3HRH1HRH2MAPK1ALDH1A1 | |
| SCHEMBL2990306 | 0.77 | PRKCQ (0.57) | HRH3HRH1HRH2KDRPRKAB2 | |
| SCHEMBL7291468 | 0.77 | HRH3 (0.92) | HRH3HRH1HRH2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K7 | HRH3 631/4885HRH1 698/4885HRH2 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.