Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24683422 | 1.00 | PARP1 (0.41) | PARP1PBKMAPK13RAF1MAPK9 | |
| SCHEMBL29845323 | 0.91 | CDK9 (0.40) | PARP1PBKMAPK13RAF1MAPK9 | |
| SCHEMBL29845331 | 0.91 | CDK9 (0.40) | PARP1PBKMAPK13RAF1MAPK9 | |
| SCHEMBL24683415 | 0.91 | CDK9 (0.40) | PARP1PBKMAPK13RAF1MAPK9 | |
| SCHEMBL30769737 | 0.90 | PARP1 (0.43) | PARP1PBKHTR6CDK9CDK1 | |
| SCHEMBL27035372 | 0.90 | PARP1 (0.43) | PARP1PBKHTR6CDK9CDK1 | |
| SCHEMBL27059733 | 0.90 | PARP1 (0.43) | PARP1PBKHTR6CDK9CDK1 | |
| Hydrochloric Acid SCHEMBL30769827 | 0.90 | CDK9 (0.40) | PARP1PBKMAPK13RAF1MAPK9 | |
| Hydrochloric Acid SCHEMBL27035376 | 0.90 | CDK9 (0.40) | PARP1PBKMAPK13RAF1MAPK9 | |
| Hydrochloric Acid SCHEMBL27147682 | 0.90 | CDK9 (0.40) | PARP1PBKMAPK13RAF1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187518-A1 | SUBSTITUTED 4-PIPERIDINYL-IMIDAZO[4,5-B]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2022-09-09 | — | — | WO | disclosed |