Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18864488 | 0.86 | POLB (0.45) | MEN1KMT2ATDP1RAB9APKM | |
| SCHEMBL3700292 | 0.85 | TUBB4A (0.43) | MEN1KMT2ATDP1RAB9APKM | |
| SCHEMBL29663634 | 0.85 | TUBB4A (0.43) | MEN1KMT2ATDP1RAB9APKM | |
| SCHEMBL21591732 | 0.84 | NNMT (0.41) | MEN1KMT2ATDP1RAB9ACLK1 | |
| SCHEMBL29757613 | 0.84 | NNMT (0.41) | MEN1KMT2ATDP1RAB9ACLK1 | |
| SCHEMBL847606 | 0.84 | EGFR (0.43) | KMT2ARAB9APKMCLK1DYRK1A | |
| SCHEMBL13199889 | 0.79 | MEN1 (0.40) | MEN1KMT2ATDP1RAB9APKM | |
| SCHEMBL12123076 | 0.79 | PKM (0.34) | MEN1KMT2ARAB9APKMCLK1 | |
| SCHEMBL1325615 | 0.79 | PDE4B (0.38) | RAB9APKMCLK1DYRK1ADYRK1B | |
| SCHEMBL3778708 | 0.79 | TUBB4A (0.46) | MEN1KMT2ARAB9APKMMLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322947-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF RIP2 KINASE, COMPOSITION AND APPLICATION THEREOF | Accro Bioscience (HK) Limited (HK) | 2024-02-21 | — | — | EP | disclosed |
| EP-4301756-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| CN-117295737-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-12-26 | — | — | CN | disclosed |
| WO-2022192760-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF RIP2 KINASE, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2022-09-15 | — | — | WO | disclosed |
| WO-2022187856-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-09-09 | — | — | WO | disclosed |