Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | MYC | P01106 | 2/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945483 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KEAP1NFE2L2MAPK1 | |
| SCHEMBL3407348 | 0.81 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KEAP1NFE2L2MAPK1 | |
| SCHEMBL31267853 | 0.81 | L3MBTL1 (0.41) | ALDH1A1SMN1; SMN2KDM4EKMT2ANPC1 | |
| SCHEMBL10426645 | 0.79 | POLB (0.45) | ALDH1A1SMN1; SMN2KEAP1NFE2L2MAPK1 | |
| SCHEMBL30067156 | 0.78 | KEAP1 (0.46) | ALDH1A1SMN1; SMN2KEAP1NFE2L2MAPK1 | |
| SCHEMBL31510037 | 0.75 | MEN1 (0.42) | ALDH1A1SMN1; SMN2KEAP1NFE2L2MAPK1 | |
| SCHEMBL14394737 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KEAP1NFE2L2MAPK1 | |
| SCHEMBL21609841 | 0.74 | KEAP1 (0.42) | ALDH1A1SMN1; SMN2KEAP1NFE2L2MAPK1 | |
| SCHEMBL11985860 | 0.71 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL14462651 | 0.71 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| EP-4301756-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |
| WO-2022187856-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-09-09 | — | — | WO | disclosed |