Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 10/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753923 | 1.00 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL23761304 | 0.78 | MAPK14 (0.40) | HSP90AB1MAPK14 | |
| SCHEMBL28852766 | 0.75 | MC4R (0.35) | CSNK1DMAPK14 | |
| SCHEMBL26505595 | 0.75 | USP1 (0.38) | HTR1ADRD4HTR1BDRD3HSP90AB1 | |
| SCHEMBL31515757 | 0.74 | ALDH1A1 (0.37) | ABL1DPP4 | |
| SCHEMBL23753853 | 0.73 | DPP4 (0.41) | HTR1ADRD4HTR1BDRD3DPP4 | |
| SCHEMBL23753854 | 0.73 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL21116203 | 0.73 | USP8 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL23941153 | 0.72 | CCNT1 (0.40) | — | |
| SCHEMBL30185841 | 0.72 | CCNT1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135648-B | Dihydronaphthyridones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-115135648-A | Dihydronaphthyridinone compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2022-09-30 | — | — | CN | disclosed |