Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.41 |
| ▸ | CCND1 | P24385 | 9/20 | 0.41 |
| ▸ | CDK2 | P24941 | 6/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27159654 | 0.72 | TYMS (0.44) | CDK4CCND1CDK2PIM1CHEK1 | |
| SCHEMBL17941961 | 0.71 | METAP2 (0.47) | CDK2PIM1CHEK1FLT3METAP2 | |
| SCHEMBL31212369 | 0.71 | METAP2 (0.47) | CDK2PIM1CHEK1FLT3METAP2 | |
| SCHEMBL10153752 | 0.71 | PARP1 (0.56) | CDK4CCND1CDK2PIM1CHEK1 | |
| SCHEMBL14486519 | 0.69 | CA12 (0.44) | CDK4CCND1CDK2PIM1CHEK1 | |
| SCHEMBL2457623 | 0.69 | CHEK1 (0.69) | PIM1CHEK1FLT3METAP2AURKA | |
| SCHEMBL14269353 | 0.68 | ALOX15 (0.39) | PIM1CHEK1FLT3METAP2AURKA | |
| SCHEMBL22473899 | 0.68 | CHEK1 (0.46) | PIM1CHEK1FLT3METAP2AURKA | |
| SCHEMBL20227579 | 0.67 | PARP1 (0.66) | CDK4CCND1CDK2PIM1CHEK1 | |
| SCHEMBL30466768 | 0.67 | PARP1 (0.66) | CDK4CCND1CDK2PIM1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022173849-A1 | (HETERO)ARYLAMINO-CYCLOHEXYL-SULFONYL DERIVATIVES AS CCR6 INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2022-08-18 | — | — | WO | disclosed |