Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986897 | 0.84 | SMN1; SMN2 (0.50) | MEN1KMT2ASMN1; SMN2BACE1BACE2 | |
| SCHEMBL2981596 | 0.84 | RAB9A (0.46) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2983850 | 0.83 | MEN1 (0.46) | MEN1KMT2ASMN1; SMN2BACE1BACE2 | |
| SCHEMBL3657141 | 0.80 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL2982195 | 0.78 | NPY2R (0.41) | MEN1KMT2ASMN1; SMN2BACE1CTSD | |
| SCHEMBL2984449 | 0.77 | BACE1 (0.52) | BACE1BACE2CTSDCTSE | |
| SCHEMBL2972354 | 0.71 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4681925 | 0.68 | MEN1 (0.86) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2983179 | 0.66 | NPC1 (0.49) | MEN1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL22679410 | 0.66 | NPC1 (0.61) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786155-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-08-31 | — | — | US | claimed |
| US-7786155-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-08-31 | — | — | US | disclosed |
| EP-2212295-A2 | 4-PHENYL-5-OXO-IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEROF | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009050201-A2 | 4-PHENYL-5-OXO-IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEROF | NOVARTIS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
| US-20090099244-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099244-A1 | ORGANIC COMPOUNDS | SLCO4C1, SLC10A6, SLCO1B1 | MEN1 235/4885KMT2A 1654/4885SMN1; SMN2 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.