Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 5/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28046034 | 0.88 | TPMT (0.49) | TPMTPTGS2HPGDALDH1A1CA12 | |
| SCHEMBL29856679 | 0.86 | HPGD (0.39) | LMNAMAPK1HTTRAB9AHPGD | |
| SCHEMBL29856395 | 0.86 | KDM4E (0.43) | LMNAHPGDALDH1A1CA12CA1 | |
| SCHEMBL1458628 | 0.82 | LMNA (0.58) | LMNAMAPK1HTTRAB9ATPMT | |
| SCHEMBL9787608 | 0.82 | TPMT (0.60) | LMNAMAPK1HTTTPMTPTGS2 | |
| SCHEMBL10323237 | 0.81 | TPMT (0.61) | LMNAHTTTPMTHPGDALDH1A1 | |
| SCHEMBL10322905 | 0.81 | TPMT (0.42) | TPMTPTGS2HPGDALDH1A1CA12 | |
| SCHEMBL31318546 | 0.81 | TPMT (0.61) | HTTTPMTHPGDALDH1A1CA12 | |
| SCHEMBL10323282 | 0.81 | TPMT (0.61) | TPMTPTGS2HPGDALDH1A1CA12 | |
| SCHEMBL10323576 | 0.80 | CYP2C9 (0.42) | TPMTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |