Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.35 |
| ▸ | EYA3 | Q99504 | 4/20 | 0.35 |
| ▸ | TTR | P02766 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | EYA2 | O00167 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856228 | 0.85 | ADORA3 (0.46) | ADORA3ADORA2ASLC22A12SLC22A6SLC22A8 | |
| SCHEMBL29856340 | 0.83 | ROCK2 (0.38) | ADORA3ADORA2ASLC22A12ROCK2LMNA | |
| SCHEMBL29856189 | 0.81 | SLC22A12 (0.42) | ADORA3ADORA2ASLC22A12SLC22A6SLC22A8 | |
| SCHEMBL29856212 | 0.81 | ADORA3 (0.40) | ADORA3ADORA2ASLC22A12SLC22A6SLC22A8 | |
| SCHEMBL29856309 | 0.80 | SLC22A12 (0.39) | ADORA3ADORA2ASLC22A12SLC22A6SLC22A8 | |
| SCHEMBL29856428 | 0.75 | NTRK1 (0.46) | ADORA3ADORA2ASLC22A12SLC22A6SLC22A8 | |
| SCHEMBL29856177 | 0.74 | KDM5A (0.49) | ADORA3SLC22A12SLC22A6SLC22A8CYP2C19 | |
| SCHEMBL29856281 | 0.72 | SLC22A12 (0.42) | ADORA3SLC22A12SLC22A6SLC22A8CYP2C19 | |
| SCHEMBL7083487 | 0.67 | ADORA3 (0.60) | ADORA3ADORA2AROCK2MAPTKDM5A | |
| SCHEMBL29369522 | 0.67 | ADORA3 (0.60) | ADORA3ADORA2AROCK2MAPTKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |