Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856242 | 0.90 | SRD5A2 (0.46) | PPARGPPARASRD5A2RAB9ACYP19A1 | |
| SCHEMBL29856194 | 0.87 | SRD5A2 (0.47) | PPARGPPARASRD5A2RAB9ACYP19A1 | |
| SCHEMBL29856443 | 0.85 | CNR2 (0.41) | PPARGPPARAALDH1A1GAAROCK2 | |
| SCHEMBL29856187 | 0.81 | SRD5A2 (0.47) | PPARGSRD5A2RAB9ACYP19A1CYP11B1 | |
| SCHEMBL29856398 | 0.76 | SRD5A2 (0.46) | PPARGPPARASRD5A2RAB9ACYP19A1 | |
| SCHEMBL29856267 | 0.76 | SRD5A2 (0.46) | PPARGSRD5A2RAB9ACYP19A1CYP11B1 | |
| SCHEMBL29856197 | 0.76 | KDM5A (0.39) | PPARGRAB9AALDH1A1MAPTGAA | |
| SCHEMBL29856292 | 0.76 | SRD5A2 (0.46) | PPARGSRD5A2RAB9ACYP19A1CYP11B1 | |
| SCHEMBL29856222 | 0.73 | SRD5A2 (0.47) | PPARGSRD5A2RAB9ACYP19A1CYP11B1 | |
| SCHEMBL29856192 | 0.72 | KDM5A (0.50) | CYP19A1HTTMAPTROCK2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |