Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856192 | 0.86 | KDM5A (0.50) | ROCK2KDM5AHDAC2HDAC6 | |
| SCHEMBL29856197 | 0.85 | KDM5A (0.39) | CNR2GAATSHRHSD17B10ROCK2 | |
| SCHEMBL29856296 | 0.85 | PPARG (0.45) | CNR2GAAROCK2HDAC2HDAC6 | |
| SCHEMBL29856214 | 0.83 | KDM5A (0.40) | ROCK2KDM5AHDAC2HDAC6LMNA | |
| SCHEMBL29856217 | 0.76 | TUBB4A (0.41) | CNR2KDM5AHDAC2HDAC6LMNA | |
| SCHEMBL29856242 | 0.73 | SRD5A2 (0.46) | GAAROCK2KDM5AHDAC2HDAC6 | |
| SCHEMBL29856503 | 0.72 | ADORA3 (0.44) | ROCK2LMNAPOLBKDM4EHPGD | |
| SCHEMBL29856177 | 0.71 | KDM5A (0.49) | TSHRHSD17B10ROCK2KDM5ALMNA | |
| SCHEMBL29856229 | 0.70 | ALOX15 (0.39) | HSD17B10LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL29856230 | 0.69 | ROCK2 (0.42) | ROCK2HDAC2HDAC6LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |