Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22502923 | 0.79 | DYRK1A (0.37) | MAPTDYRK1AMAOABCHEACHE | |
| SCHEMBL24896258 | 0.73 | KDM4E (0.50) | ACSS2MAPT | |
| SCHEMBL30220608 | 0.72 | L3MBTL1 (0.50) | MAPTMEN1KMT2A | |
| SCHEMBL30593081 | 0.68 | MAPT (0.40) | ACSS2MAPTTRPA1CYP1A2CYP3A4 | |
| SCHEMBL22863378 | 0.68 | MAPT (0.40) | ACSS2MAPTTRPA1CYP1A2CYP3A4 | |
| SCHEMBL7016987 | 0.68 | TLR8 (0.49) | MAPTACHERPS6KA5TRPA1CYP1A2 | |
| SCHEMBL29856250 | 0.67 | LOXL2 (0.39) | MAPTDYRK1ATRPA1CYP1A2CYP3A4 | |
| SCHEMBL22502897 | 0.65 | ALKBH5 (0.38) | CYP1A2DHFRMEN1KMT2A | |
| SCHEMBL21117365 | 0.65 | CCR1 (0.31) | CCR1CCR5CCR8 | |
| SCHEMBL9883177 | 0.65 | ROCK1 (0.42) | MAPTACHETRPA1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |