Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 13/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5572132 | 0.99 | OPRM1 (0.50) | OPRM1OPRL1SLC6A2SLC6A4KDM1A | |
| SCHEMBL4051249 | 0.83 | OPRL1 (0.63) | OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL4056476 | 0.81 | OPRL1 (0.61) | OPRM1OPRL1 | |
| SCHEMBL316598 | 0.81 | OPRL1 (0.66) | OPRM1OPRL1SLC6A2SLC6A4KDM1A | |
| Hydrochloric Acid SCHEMBL5572136 | 0.80 | OPRL1 (0.64) | OPRM1OPRL1SLC6A2SLC6A4KDM1A | |
| SCHEMBL4344633 | 0.80 | OPRL1 (0.49) | OPRM1OPRL1SLC6A2SLC6A4KDM1A | |
| SCHEMBL1044573 | 0.78 | OPRM1 (0.50) | OPRM1OPRL1SLC6A2SLC6A4KDM1A | |
| SCHEMBL5290991 | 0.75 | KMT2A (0.43) | OPRM1OPRL1 | |
| SCHEMBL4344782 | 0.75 | SLC6A4 (0.62) | OPRM1OPRL1SLC6A2SLC6A4KDM1A | |
| SCHEMBL22538377 | 0.74 | OPRM1 (0.52) | OPRM1OPRL1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745009-B1 | HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2012-11-14 | — | — | EP | claimed |
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | claimed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | claimed |
| US-20070129369-A1 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-06-07 | — | — | US | claimed |
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
| US-20070129369-A1 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129369-A1 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds | DDC, DPYD, PKD1 | OPRM1 2315/4885OPRL1 2457/4885SLC6A2 3205/4885 |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | DPYD, PKD1, AOC1 | OPRM1 1483/4885OPRL1 1292/4885SLC6A2 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.