Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 10/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | SELL | P14151 | 1/20 | 0.32 |
| ▸ | SELP | P16109 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 3/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1043169 | 1.00 | RAPGEF4 (0.40) | RAPGEF4HDAC1HDAC6CA1CA2 | |
| SCHEMBL8062622 | 0.86 | KDM1A (0.39) | RAPGEF4HDAC1HDAC6SELLSELP | |
| SCHEMBL156826 | 0.80 | RAPGEF4 (0.45) | RAPGEF4CA1CA2MMP1MMP2 | |
| SCHEMBL8309828 | 0.79 | RAPGEF4 (0.40) | RAPGEF4KDM1AKDM1B | |
| SCHEMBL27213046 | 0.79 | AKR1B1 (0.36) | RAPGEF4HDAC1HDAC6CA1CA2 | |
| SCHEMBL29664557 | 0.79 | NQO2 (0.32) | KDM1AKDM1B | |
| SCHEMBL13550059 | 0.79 | NQO2 (0.32) | KDM1AKDM1B | |
| SCHEMBL1109753 | 0.77 | RAPGEF4 (0.43) | RAPGEF4CA1CA2MMP1MMP2 | |
| SCHEMBL14744248 | 0.75 | ALDH1A1 (0.38) | MAPK1KDM1AKDM1B | |
| SCHEMBL21957498 | 0.75 | ALDH1A1 (0.38) | RAPGEF4CA1MAPK1KDM1AKDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045039-A1 | INHIBITING HUMAN INTEGRIN ALPHA4BETA7 | Morphic Therapeutic, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |