Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 14/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29864087 | 0.88 | USP1 (0.43) | USP1MMP13PTGS2 | |
| SCHEMBL25791870 | 0.88 | USP1 (0.43) | USP1MMP13PTGS2 | |
| SCHEMBL29863823 | 0.86 | USP1 (0.39) | USP1HSD11B1PTGS2PTGS1 | |
| SCHEMBL27031444 | 0.86 | LOXL2 (0.41) | USP1HSD11B1PTGS2PTGS1 | |
| SCHEMBL29879001 | 0.86 | LOXL2 (0.41) | USP1HSD11B1PTGS2PTGS1 | |
| SCHEMBL30966298 | 0.85 | USP1 (0.44) | USP1MMP13PTGS2PTGS1 | |
| SCHEMBL27031631 | 0.82 | HTT (0.43) | PTGS2HTTPTGS1 | |
| SCHEMBL23244678 | 0.80 | USP1 (0.45) | USP1PTGS2 | |
| SCHEMBL31496744 | 0.80 | USP1 (0.38) | USP1MMP13PTGS2HTTPTGS1 | |
| SCHEMBL29864018 | 0.78 | HSD11B1 (0.35) | USP1HSD11B1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291559-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Tango Therapeutics, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022174184-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2022-08-18 | — | — | WO | disclosed |