Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888893 | 0.87 | CRHBP (0.33) | CRHBPCRHR2 | |
| SCHEMBL3797084 | 0.78 | KMT2A (0.36) | — | |
| SCHEMBL3790098 | 0.77 | CRHBP (0.30) | CRHBPCRHR2 | |
| SCHEMBL298185 | 0.75 | CRHBP (0.34) | CRHBPCRHR2 | |
| SCHEMBL30211022 | 0.72 | — | — | |
| SCHEMBL297498 | 0.71 | — | — | |
| SCHEMBL3785748 | 0.71 | — | — | |
| SCHEMBL4147880 | 0.70 | — | — | |
| SCHEMBL21904731 | 0.69 | LMNA (0.32) | — | |
| SCHEMBL3441740 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427437-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128058-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| WO-2009153179-A1 | PYRROLIDINE DERIVATIVES AS NK2 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-23 | — | — | WO | disclosed |