Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PYGL | P06737 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29472228 | 0.87 | IDO1 (0.38) | ALDH1A1PYGLGAAMAPTNPSR1 | |
| SCHEMBL5447593 | 0.84 | PPIB (0.50) | ALDH1A1PYGLGAANPSR1CTSL | |
| SCHEMBL17336383 | 0.84 | MTNR1A (0.48) | HSD17B1HSD17B2 | |
| SCHEMBL17336558 | 0.84 | ALDH1A1 (0.41) | ALDH1A1GAAKDM4EIDO1KMT2A | |
| SCHEMBL8033648 | 0.83 | ALDH1A1 (0.41) | ALDH1A1PYGLNPSR1KLKB1KDM4E | |
| SCHEMBL22289644 | 0.83 | PARP14 (0.39) | — | |
| SCHEMBL8426236 | 0.82 | KDM4E (0.41) | ALDH1A1NPC1GAAMAPTNPSR1 | |
| SCHEMBL22289671 | 0.82 | KMT2A (0.42) | CTSLKMT2A | |
| SCHEMBL26599038 | 0.80 | SUV39H2 (0.49) | ALDH1A1NPC1GAAMAPTNPSR1 | |
| SCHEMBL29004748 | 0.78 | HTR3E (0.51) | ALDH1A1NPC1GAAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790726-B2 | Monocyclic and bicyclic compounds and methods of use | CHEMOCENTRYX, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-7786157-B2 | OXO-imidazolidines as modulators of chemokine receptors | CHEMOCENTRYX, INC. (US) | 2010-08-31 | — | — | US | disclosed |
| EP-1931348-A4 | MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20080269280-A1 | OXO-IMIDAZOLIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2008-10-30 | — | — | US | disclosed |
| EP-1931348-A2 | MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-06-18 | — | — | EP | disclosed |
| US-20070066583-A1 | Monocyclic and bicyclic compounds and methods of use | CHEMOCENTRYX, INC. (US) | 2007-03-22 | — | — | US | disclosed |
| WO-2007022257-A2 | MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066583-A1 | Monocyclic and bicyclic compounds and methods of use | CCR1, CCR3, CCR4 | ALDH1A1 1533/4885PYGL 3259/4885NPC1 328/4885 |
| US-20080269280-A1 | OXO-IMIDAZOLIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR1, CCR3, CCR4 | ALDH1A1 2544/4885PYGL 3815/4885NPC1 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.